目的 探讨口腔贴膜不同表面粗糙度与黏膜黏附性能之间的关系。方法 以不同粗糙度的砂纸为母版制作聚二甲基硅氧烷反模板,并进一步采用流延法制备口腔贴膜。观察所得贴膜微观形态,并分别测定其体外黏附力、剪切力及黏附时间。结果 壳聚糖贴膜的黏膜黏附性能较优于白及胶贴膜。表面粗糙度不同的贴膜之间体外黏附性能差异显著,其中#400贴膜的性能最优。结论 表面粗糙度对口腔贴膜的体外黏膜黏附性能存在显著影响,值得进一步研究。
Abstract
OBJECTIVE To study the relationship between surface roughness and muc-oadhesion properties of oral film. METHODS Polydimethylsiloxane reverse templates were fabricated from sandpapers with different roughness, and were used as the m-old to prepare films by solvent casting method. The obtained films were then evaluat-ed for mucoadhesive force, shear force, mucoadhesion time, and their morpholog-y was investigated by scanning electron microscopy (SEM). RESULTS Films of c-hitosan showed more favorable mucoadhesive performance than those of Bletilla striata gum. Generally, the prepared films exhibited different mucoadhesion properties, among which #400 films showed the best performance. CONCLUSION The mucoadhesion prop-erties of films were significantly affected by their surface roughness, which are wo-rthy of further study.
关键词
口腔贴膜 /
黏附性能 /
表面粗糙度
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Key words
oral film /
mucoadhesion properties /
surface roughness
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中图分类号：
R944
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参考文献
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脚注
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基金
国家自然科学基金资助项目(81160521);宁夏自然科学基金资助项目(NZ1226)
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